Association of PRMT6, PEX10 and SOX5 genetic variants with idiopathic male infertility: Evidence from North Macedonian population and an updated meta-analysis

PRMT6, PEX10 and SOX5 genetic variants were identified as male infertility-associated loci in a genome-wide association study further validated various populations. Still, the results of previous case-control studies varied, which could be due to differences participants? ethnic backgrounds. The main purpose present was evaluate supposed these with idiopathic infertility North Macedonian population. Furthermore, we aimed conduct systematic quantitative data synthesis includes on same issue other European non-European A total 137 men from Macedonia diagnosed 130 age-matched fertile controls included study. PCR-RFLP method used for genotyping. Meta-analysis performed by OpenMeta-analyst statistical software. Variants rs10842262 SOX5, rs2477686 rs12097821 PRMT6 showed lack statistically significant genotype distributions between control group. allele G frequency significantly increased poor sperm concentration (P= 0.024, OR = 2.10, 95%CI 1.08-4.06). risk infertility. Our obtained population supported reports involvement basis meta-analysis confirmed occurrence. additional are needed support findings.